SYNTHETIC PEPTIDE MIMICS OF THE L1 PROTEIN OF HPV, HPV DIAGNOSIS METHOD, HPV DIAGNOSIS SYSTEM, PHARMACEUTICAL COMPOSITION AND USE THEREOF IN THE TREATMENT OR PREVENTION OF HPV

The present invention relates to the selection and characterization of synthetic peptides designed and synthesized from analysis of mimotope phage clones of the immunological epitope of the L1 protein of the human papillomavirus (HPV) The synthesized peptides were immunoreactive and able to detect IgA antibodies in samples of bodily fluids from patients with HPV, and could be used in the diagnosis of HPV. In addition to this, said peptides were able to trigger an in vivo immune response. The present invention relates to the selection, characterization and use of these novel synthesized peptides both for diagnosing and for treating and/or preventing HPV. The present invention also describes a method for diagnosing HPV, a pharmaceutical composition and the use thereof. La présente invention concerne la sélection et la caractérisation de peptides synthétiques, conçus et synthétisés à partir de l'analyse de clones de phages mimétopes de l'épitope immunologique de la protéine L1 du papillomavirus humain (PVH). Les peptides synthétisés sont immunoréactifs et permettent de détecter des anticorps IgA dans des échantillons de liquides corporels de patients atteints du PVH, pouvant ainsi être utilisés dans le diagnostic du PVH. Par ailleurs, il permettent de provoquer une réponse immunitaire in vivo. La présente invention concerne la sélection, la caractérisation et l'utilisation de ces nouveaux peptides synthétisés tant pour le diagnostic que pour le traitement et/ou la prévention du PVH. La présente invention concerne en outre une méthode de diagnostic du PVH, une composition pharmaceutique et leur utilisation. A presente invenção refere-se à seleção e caracterização de peptídeos sintéticos, projetados e sintetizados a partir da análise de clones de fagos mimetopos do epítopo imunológico da proteína L1 do papilomavírus humano (HPV). Os peptídeos sintetizados foram imunorreativos e capazes de detectar anticorpos IgA em amostras de fluidos corporais de pacientes com HPV, podendo ser utilizados no diagnóstico do HPV. Além disso, eles foram capazes de provocar resposta imune in vivo. A presente inveção refere-se à seleção, caracterização e utilização desses novos peptídeos sintetizados tanto para o diagnóstico quanto para o tratamento e/ou profilaxia do HPV. A presente invenção ainda descreve um método de diagnóstico de HPV, uma composição farmacêutica e o uso destes.