COMPOSITIONS OF IL-6/IL-6R ANTIBODIES AND METHODS OF USE THEREOF

The present disclosure provides compositions and methods for the treatment of coronavirus infections, such as SAR-CoV, SARS-CoV-2, and MERS-CoV. The compositions include antibodies targeting the IL-6 receptor complex, antibodies targeting CD3, dactinomycin, and combinations thereof. The methods of t...

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Bibliographische Detailangaben
Hauptverfasser:	SHAILUBHAI, Kunwar, JACOB, Jules S, PALEJWALA, Vaseem A, CERRONE, Gabriele
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides compositions and methods for the treatment of coronavirus infections, such as SAR-CoV, SARS-CoV-2, and MERS-CoV. The compositions include antibodies targeting the IL-6 receptor complex, antibodies targeting CD3, dactinomycin, and combinations thereof. The methods of treatment include administration of antibodies and combination therapies to reduce or eliminate symptoms associated with coronavirus infection or pulmonary inflammatory disease. La présente invention concerne des compositions et des méthodes destinés au traitement d'infections à coronavirus, telles que SAR-CoV, SARS-CoV-2 et MERS-CoV. Les compositions comprennent des anticorps ciblant le complexe du récepteur IL-6, des anticorps ciblant CD3, la dactinomycine et des associations de ceux-ci. Les méthodes de traitement comprennent l'administration d'anticorps et de polythérapies pour réduire ou éliminer les symptômes associés à une infection à coronavirus ou à une maladie inflammatoire pulmonaire.