IN-SERIES SYNTHETIC RECEPTOR AND-GATE CIRCUITS FOR EXPRESSION OF A THERAPEUTIC PAYLOAD BY ENGINEERED CELLS

Provided herein is an in-series synthetic receptor circuit for dual-antigen AND-gate control over expression of a therapeutic payload by engineered cells. In some embodiments, the circuit may be composed of a first binding-triggered transcriptional switch, a second binding-triggered transcriptional...

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Bibliographische Detailangaben

Hauptverfasser:	WILLIAMS, Jasper Z, LIM, Wendell A, SHAH, Devan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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