METHODS FOR ENGINEERING AMINO ACID AMMONIA LYASE ENZYMES AND ENZYMES THEREBY OBTAINED

Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant...

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Bibliographische Detailangaben
Hauptverfasser:	MOHAN, Karishma, MAYS, Zachary, CHAPPELL, Todd, TRIVEDI, Vikas, NAIR, Nikhil
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR IMPREGNATING OR COATING OF PAPER LAUNDERING LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PAPER NOT OTHERWISE PROVIDED FOR PAPER-MAKING PREPARATION THEREOF NOT COVERED BY SUBCLASSES D21C OR D21D PROCESSES OF PREPARING SUCH COMPOSITIONS PRODUCTION OF CELLULOSE PULP COMPOSITIONS SPIRITS TEXTILES TREATMENT OF FINISHED PAPER NOT COVERED BY CLASS B31 OR SUBCLASS D21G TREATMENT OF TEXTILES OR THE LIKE TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are methods, systems, components, and compositions for engineering enzymes. Particularly disclosed are methods, systems, components, and compositions for engineering phenylalanine ammonia-lyase (PAL) enzymes and isolating variant PAL enzymes with enhanced enzymatic properties. The variant PAL enzymes disclosed herein or obtained by the methods disclosed herein may be utilized for treating diseases or disorders characterized by elevated blood levels of phenylalanine, such as phenylketonuria (PKU). L'invention concerne des procédés, des systèmes, des composants et des compositions pour l'ingénierie d'enzymes. L'invention concerne en particulier des procédés, des systèmes, des composants et des compositions pour l'ingénierie d'enzymes phénylalanine ammonia-lyases (PAL) et l'isolement de variants d'enzymes PAL avec des propriétés enzymatiques améliorées. Les variants d'enzymes PAL décrits ici ou obtenus par les procédés décrits ici peuvent être utilisés pour traiter des maladies ou des troubles caractérisés par des taux élevés de phénylalanine, notamment la phénylcétonurie (PKU).