TOPICAL NALOXONE COMPOSITIONS AND METHODS FOR USING THE SAME

Aspects of the invention include topical naloxone compositions for locally delivering naloxone to the skin of a subject. Topical compositions according to certain embodiments are storage stable non-aqueous topical compositions that include naloxone free base and a non-aqueous vehicle, wherein the co...

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Bibliographische Detailangaben
Hauptverfasser:	HAYNES, Russell, WEN, Jianye, SUNKARA, Asha, SHUDO, Jutaro, BERNER, Bret
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	Aspects of the invention include topical naloxone compositions for locally delivering naloxone to the skin of a subject. Topical compositions according to certain embodiments are storage stable non-aqueous topical compositions that include naloxone free base and a non-aqueous vehicle, wherein the compositions are substantially free of naloxone N-oxide. Also provided are methods of using the topical compositions to locally deliver naloxone to a subject, as well as kits containing the topical naloxone compositions. Des aspects de l'invention comprennent des compositions topiques de naloxone pour administrer localement de la naloxone à la peau d'un sujet. Les compositions topiques selon certains modes de réalisation sont des compositions topiques non aqueuses stables au stockage qui comprennent une base libre de naloxone et un véhicule non aqueux, les compositions étant sensiblement exemptes de N-oxyde de naloxone. L'invention concerne également des procédés d'utilisation des compositions topiques pour administrer localement de la naloxone à un sujet, ainsi que des kits contenant les compositions topiques de naloxone.