COMBINATION THERAPY FOR TREATING MPS1

The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3', R4, R4', and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the tre...

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Bibliographische Detailangaben
Hauptverfasser:	BARRIL ALONSO, Xavier, PEREZ CARMONA, Natalia, GARCIA COLLAZO, Ana María, CUBERO JORDÀ, Elena, MAJ, Roberto
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The application is directed to compounds of formula (I) and their salts and solvates, wherein B, R1, R2, R3, R3', R4, R4', and R5 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., MPS1, optionally in combination with α-L-iduronidase or an analog or variant thereof, e.g., laronidase. L'invention concerne des composés de formule (I) et leurs sels et solvates, dans laquelle B, R1, R2, R3, R3', R4, R4', et R5 sont tels que définis dans la description, ainsi que des procédés pour leur préparation, des compositions pharmaceutiques les comprenant, et leur utilisation pour le traitement et/ou la prévention, par exemple, du MPS1, éventuellement en combinaison avec une α-L-iduronidase ou un analogue ou un variant de celle-ci, par exemple, la laronidase.