COMPOSITIONS AND METHODS FOR AUTOIMMUNITY REGULATION

COMPOSITIONS AND METHODS FOR AUTOIMMUNITY REGULATION

Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified human immune cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including autoimmune diseases. L'invention concerne des acides nucléiques...

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Bibliographische Detailangaben
Hauptverfasser: GILMORE, Dana, BAEUERLE, Patrick Alexander, GETTS, Daniel, HOFMEISTER, Robert, GUTIERREZ, Dario
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Provided herein are recombinant nucleic acids encoding T cell receptor (TCR) fusion proteins (TFPs), modified human immune cells expressing the encoded molecules, and methods of use thereof for the treatment of diseases, including autoimmune diseases. L'invention concerne des acides nucléiques recombinés codant pour des protéines de fusion (TFP) de récepteurs des lymphocytes T (TCR), des cellules immunes humaines modifiées exprimant les molécules codées, ainsi que des méthodes d'utilisation correspondantes destinées au traitement de maladies, notamment de maladies auto-immunes.