COCRYSTALS OF CANNABINOIDS

Described herein are cocrystals comprising a coformer and a cannabinoid selected from the group consisting of cannabinol and tetrahydrocannabinol. In certain embodiments, the coformer is tetramethylpyrazine, L-proline, or D-proline. Further described are methods of preparing the cocrystals starting...

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Bibliographische Detailangaben
Hauptverfasser:	COUCH, Ricky W, CARINO, Stephen A.R, BIS, Joanna A, MKRTCHYAN, Gnel, HOERNER, Joshua K
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are cocrystals comprising a coformer and a cannabinoid selected from the group consisting of cannabinol and tetrahydrocannabinol. In certain embodiments, the coformer is tetramethylpyrazine, L-proline, or D-proline. Further described are methods of preparing the cocrystals starting from a cannabinoid oil and pharmaceutical compositions comprising the cocrystals. L'invention concerne des co-cristaux comprenant un coformeur et un cannabinoïde choisi dans le groupe constitué par le cannabinol et le tétrahydrocannabinol. Dans certains modes de réalisation, le coformeur est la tétraméthylpyrazine, la L-proline, ou la D-proline. L'invention concerne en outre des procédés de préparation des co-cristaux à partir d'une huile cannabinoïde et des compositions pharmaceutiques comprenant les co-cristaux.