CONUS-BASED TOXIN PEPTIDES, NUCLEIC ACIDS ENCODING SAME AND USES THEREOF IN MODULATING NMDA RECEPTORS

CONUS-BASED TOXIN PEPTIDES, NUCLEIC ACIDS ENCODING SAME AND USES THEREOF IN MODULATING NMDA RECEPTORS

Provided herein are modified forms of Conantokin peptides, including, modified Con-P peptides, nucleic acids encoding the same and compositions thereof. Further provided are nucleic acid molecules encoding for chimeric modified conantokin polypeptides to be expressed in or on a membrane of a target...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BERLIN, Shai, ZOABI, Shaden, CARMI, Ido
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are modified forms of Conantokin peptides, including, modified Con-P peptides, nucleic acids encoding the same and compositions thereof. Further provided are nucleic acid molecules encoding for chimeric modified conantokin polypeptides to be expressed in or on a membrane of a target cells, compositions comprising the same and uses thereof for treating various neurodegenerative conditions. L'invention concerne des formes modifiées de peptides de conantokine, comprenant fes peptides Con-P modifiés, des acides nucléiques codant pour ceux-ci et des compositions de ceux-ci. L'invention concerne en outre des molécules d'acides nucléiques codant pour des polypeptides de conantokine modifiés chimériques devant être exprimés dans ou sur une membrane d'une cellule cible, des compositions les comprenant et leurs utilisations pour traiter diverses affections neurodégénératives.