COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS

COMPOSITIONS AND METHODS FOR SUBSTITUTED 7-(PIPERAZIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDINE ANALOGS AS INHIBITORS OF KRAS

In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning...

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Bibliographische Detailangaben
Hauptverfasser: ABEBE, Alemayehu, DILSHA, Kasuni, GILBERTSON, Scott, PAGBA, Cynthia
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. Selon un aspect de l'invention, l'invention concerne des composés utiles en tant qu'inhibiteurs de protéines KRAS mutantes, leurs procédés de fabrication, des compositions pharmaceutiques les comprenant, et des méthodes de traitement de cancers associés à des formes mutées de KRAS les utilisant. Le présent abrégé est destiné à servir d'outil d'exploration à des fins de recherche dans la technique particulière et n'est pas destiné à limiter la présente invention