MULTISPECIFIC BINDING MOLECULES COMPRISING LTBR AND EDB BINDING DOMAINS AND USES THEREOF

Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also...

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Bibliographische Detailangaben
Hauptverfasser:	KLUPSCH, Kristina, BERTSCHINGER, Julian, SILACCI MELKKO, Michela, LAQUERRE, Sylvie, BAERISWYL, Vanessa, SCHADE, Babette, LORENZI, Matthew, BRACK, Simon
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein. L'invention concerne des molécules de liaison multispécifiques anti-LTBR, des acides nucléiques codant pour les molécules de liaison multispécifiques anti-LTBR, des vecteurs comprenant les acides nucléiques, des cellules hôtes comprenant les vecteurs, et des compositions pharmaceutiques comprenant les molécules de liaison multispécifiques anti-LTBR. L'invention concerne également des méthodes de traitement du cancer chez un individu le nécessitant, ces méthodes comprenant l'adminitration des compositions pharmaceutiques divulguées.