COMPOUND AS CYCLIN-DEPENDENT KINASE 9 INHIBITOR AND USE THEREOF

Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs. L'invention concerne un composé tel que représenté par la formule (I) ou un sel pharmaceutiquement acceptable, un stéréoisomère, un dérivé isotopique ou un promédicament de celui-ci. Le composé présente une excellente activité en tant qu'inhibiteur de la kinase 9 dépendante de la cycline (CDK9) pour le traitement de maladies hyperprolifératives. La recherche expérimentale sur l'inhibition in v