POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compo...

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Bibliographische Detailangaben
Hauptverfasser:	RIDGILL, Mark Peter, BLACKABY, Wesley Peter, SHEPHERD, Jon, BUBERT, Christian, THOMAS, Elizabeth Jane, BROOKFIELD, Frederick Arthur, HARDICK, David James
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated. La présente invention concerne des composés de formule (I) qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique de METTL3 (sous-unité de 70 kDa de la N6-adénosine-méthyltransférase) : X-Y-Z (I), dans laquelle X, Y et Z sont chacun tels que définis dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, et les maladies auto-immunes, ainsi que d'autres maladies ou affections dans lesquelles l'activité de METTL3 est impliquée.