NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR
The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical compos...
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| creator | KIM, Sung Oog PARK, Young Shik KIM, Chang Joong LEE, Jae Yeon CHOI, Jae Hyuk JORDAN, Udell Gutterman |
| description | The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical composition for preventing or treating BET protein-related diseases comprising same.
La présente invention concerne un nouveau composé dérivé de quinazoline et son utilisation et, plus particulièrement, un nouveau composé dérivé de quinazoline de formule chimique 1 suivante ayant une activité inhibitrice dirigée contre une protéine de bromodomaine et de domaine extra-terminal (BET), et une composition pharmaceutique pour la prévention ou le traitement de maladies associées à la protéine BET le comprenant.
본 발명은 신규한 퀴나졸린 유도체 화합물 및 이의 용도에 관한 것으로, 보다 상세하게는 BET (Bromodomain Extra-Terminal) 단백질에 대하여 저해 활성을 갖는 신규한 하기 화학식 1의 퀴나졸린 유도체 화합물 및 이를 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. |
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La présente invention concerne un nouveau composé dérivé de quinazoline et son utilisation et, plus particulièrement, un nouveau composé dérivé de quinazoline de formule chimique 1 suivante ayant une activité inhibitrice dirigée contre une protéine de bromodomaine et de domaine extra-terminal (BET), et une composition pharmaceutique pour la prévention ou le traitement de maladies associées à la protéine BET le comprenant.
본 발명은 신규한 퀴나졸린 유도체 화합물 및 이의 용도에 관한 것으로, 보다 상세하게는 BET (Bromodomain Extra-Terminal) 단백질에 대하여 저해 활성을 갖는 신규한 하기 화학식 1의 퀴나졸린 유도체 화합물 및 이를 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.</description><language>eng ; fre ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210603&DB=EPODOC&CC=WO&NR=2021107657A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210603&DB=EPODOC&CC=WO&NR=2021107657A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIM, Sung Oog</creatorcontrib><creatorcontrib>PARK, Young Shik</creatorcontrib><creatorcontrib>KIM, Chang Joong</creatorcontrib><creatorcontrib>LEE, Jae Yeon</creatorcontrib><creatorcontrib>CHOI, Jae Hyuk</creatorcontrib><creatorcontrib>JORDAN, Udell Gutterman</creatorcontrib><title>NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR</title><description>The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical composition for preventing or treating BET protein-related diseases comprising same.
La présente invention concerne un nouveau composé dérivé de quinazoline et son utilisation et, plus particulièrement, un nouveau composé dérivé de quinazoline de formule chimique 1 suivante ayant une activité inhibitrice dirigée contre une protéine de bromodomaine et de domaine extra-terminal (BET), et une composition pharmaceutique pour la prévention ou le traitement de maladies associées à la protéine BET le comprenant.
본 발명은 신규한 퀴나졸린 유도체 화합물 및 이의 용도에 관한 것으로, 보다 상세하게는 BET (Bromodomain Extra-Terminal) 단백질에 대하여 저해 활성을 갖는 신규한 하기 화학식 1의 퀴나졸린 유도체 화합물 및 이를 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDx8w9z9VEIDPX0c4zy9_H0c1UIcnXxj1BwcQ3yDHMM8Qxz1VFw9HNRCA12VXAMVnByDVHw9PPwdPIM8Q_iYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkaGhgbmZqbmjobGxKkCAKSjKlw</recordid><startdate>20210603</startdate><enddate>20210603</enddate><creator>KIM, Sung Oog</creator><creator>PARK, Young Shik</creator><creator>KIM, Chang Joong</creator><creator>LEE, Jae Yeon</creator><creator>CHOI, Jae Hyuk</creator><creator>JORDAN, Udell Gutterman</creator><scope>EVB</scope></search><sort><creationdate>20210603</creationdate><title>NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR</title><author>KIM, Sung Oog ; PARK, Young Shik ; KIM, Chang Joong ; LEE, Jae Yeon ; CHOI, Jae Hyuk ; JORDAN, Udell Gutterman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2021107657A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; kor</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KIM, Sung Oog</creatorcontrib><creatorcontrib>PARK, Young Shik</creatorcontrib><creatorcontrib>KIM, Chang Joong</creatorcontrib><creatorcontrib>LEE, Jae Yeon</creatorcontrib><creatorcontrib>CHOI, Jae Hyuk</creatorcontrib><creatorcontrib>JORDAN, Udell Gutterman</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIM, Sung Oog</au><au>PARK, Young Shik</au><au>KIM, Chang Joong</au><au>LEE, Jae Yeon</au><au>CHOI, Jae Hyuk</au><au>JORDAN, Udell Gutterman</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR</title><date>2021-06-03</date><risdate>2021</risdate><abstract>The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical composition for preventing or treating BET protein-related diseases comprising same.
La présente invention concerne un nouveau composé dérivé de quinazoline et son utilisation et, plus particulièrement, un nouveau composé dérivé de quinazoline de formule chimique 1 suivante ayant une activité inhibitrice dirigée contre une protéine de bromodomaine et de domaine extra-terminal (BET), et une composition pharmaceutique pour la prévention ou le traitement de maladies associées à la protéine BET le comprenant.
본 발명은 신규한 퀴나졸린 유도체 화합물 및 이의 용도에 관한 것으로, 보다 상세하게는 BET (Bromodomain Extra-Terminal) 단백질에 대하여 저해 활성을 갖는 신규한 하기 화학식 1의 퀴나졸린 유도체 화합물 및 이를 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR |
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