NOVEL QUINAZOLINE REDOX DERIVATIVE, AND USE AS BET INHIBITOR

The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical compos...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Sung Oog, PARK, Young Shik, KIM, Chang Joong, LEE, Jae Yeon, CHOI, Jae Hyuk, JORDAN, Udell Gutterman
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a novel quinazoline derivative compound and a use thereof and, more specifically, to a novel quinazoline derivative compound of the following chemical formula 1 having inhibitory activity against a bromodomain extra-terminal (BET) protein, and a pharmaceutical composition for preventing or treating BET protein-related diseases comprising same. La présente invention concerne un nouveau composé dérivé de quinazoline et son utilisation et, plus particulièrement, un nouveau composé dérivé de quinazoline de formule chimique 1 suivante ayant une activité inhibitrice dirigée contre une protéine de bromodomaine et de domaine extra-terminal (BET), et une composition pharmaceutique pour la prévention ou le traitement de maladies associées à la protéine BET le comprenant. 본 발명은 신규한 퀴나졸린 유도체 화합물 및 이의 용도에 관한 것으로, 보다 상세하게는 BET (Bromodomain Extra-Terminal) 단백질에 대하여 저해 활성을 갖는 신규한 하기 화학식 1의 퀴나졸린 유도체 화합물 및 이를 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.