SECRETABLE PROTEIN INDUCED IMMUNE TOLERIZATION AND TREATMENT OF AUTOIMMUNE, ALLERGIC AND OTHER DISEASES AND DISORDERS

Nucleic acids encoding fusion proteins that contain an unwanted antigen and a leader sequence for cell secretion are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat autoimmune, all...

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Bibliographische Detailangaben
Hauptverfasser:	QUINN, William, MINGOZZI, Federico, ANDERSON, David William, GURDA, Brittney L, YAZICIOGLU, Mustafa N
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	Nucleic acids encoding fusion proteins that contain an unwanted antigen and a leader sequence for cell secretion are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat autoimmune, allergic and other diseases and disorders, such as multiple sclerosis. L'invention concerne des acides nucléiques codant pour des protéines hybrides qui contiennent un antigène indésirable et une séquence de tête pour la sécrétion cellulaire. L'invention concerne également des cassettes d'expression, des vecteurs, des cellules et des lignées cellulaires contenant les acides nucléiques, ainsi que des procédés d'utilisation des acides nucléiques pour traiter des maladies et des troubles auto-immuns, allergiques et autres, tels que la sclérose en plaques.