HIGH CONCENTRATION ANTI-C5 ANTIBODY FORMULATIONS

The present disclosure relates to stable aqueous solutions comprising a high concentration of an anti-C5 antibody (e.g., ravulizumab) and methods for preparing the solutions. The disclosure also provides methods for treating or preventing complement-associated disorders, such as paroxysmal nocturnal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MASON, Bruce, PHILOMINATHAN, Leena
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present disclosure relates to stable aqueous solutions comprising a high concentration of an anti-C5 antibody (e.g., ravulizumab) and methods for preparing the solutions. The disclosure also provides methods for treating or preventing complement-associated disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and thrombotic microangiopathy (TMA), including atypical hemolytic uremic syndrome (aHUS) using the solutions. Also featured are therapeutic kits containing one or more of the solutions. La présente invention concerne des solutions aqueuses stables comprenant une concentration élevée d'un anticorps anti-C5 (par exemple, le ravulizumab) et des procédés de préparation de ces solutions. L'invention concerne également des procédés de traitement ou de prévention de troubles associés au complément, tels que l'hémoglobinurie paroxystique nocturne (PNH) et la microangiopathie thrombotique (TMA), y compris le syndrome hémolytique et urémique atypique (aHUS), à l'aide desdites solutions. L'invention concerne également des kits thérapeutiques contenant une ou plusieurs de ces solutions.