LOW-MOLECULAR-WEIGHT CHONDROITIN SULFATE AND PREPARATION METHOD THEREFOR

Disclosed are a low-molecular-weight chondroitin sulfate and a preparation method therefor. Macromolecular chondroitin sulfate is used as a raw material. A low-molecular-weight chondroitin sulfate having an average molecular weight of less than 1000 daltons can be obtained by means of a production p...

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Hauptverfasser: CUI, Huaiyan, TANG, Chuangen, LI, Degeng, WANG, Yin, XU, Yonggang, CHEN, Song, ZHANG, Haoning, LIANG, Xuguang
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:Disclosed are a low-molecular-weight chondroitin sulfate and a preparation method therefor. Macromolecular chondroitin sulfate is used as a raw material. A low-molecular-weight chondroitin sulfate having an average molecular weight of less than 1000 daltons can be obtained by means of a production process comprising chondroitin sulfate lyase degradation, deproteinization, filtration sterilization, drying, etc. With respect to the low-molecular-weight chondroitin sulfate, the molecular weight distribution range is narrow, the proportion of chondroitin sulfate disaccharide is 43% to 60%, the proportion of chondroitin sulfate tetrasaccharide is 30% to 45%, the sum of the contents of the chondroitin sulfate disaccharide and the chondroitin sulfate tetrasaccharide is greater than 87%, the total content of oligosaccharides in the low-molecular-weight chondroitin sulfate is not less than 97%, and the protein content is not more than 0.5%. Compared with common marketed macromolecular chondroitin sulfate, the product