LIQUID CRYSTALLINE STRUCTURE-FORMING OMEGA-3-FATTY ACID COMPOSITION

The present invention relates to a liquid crystalline structure-forming omega-3-fatty acid composition and, more specifically, provides an omega-3-fatty acid composition comprising: amphoteric lipids which form liquid crystalline structures when exposed to aqueous media such as gastrointestinal juice; omega-3 fatty acids or derivatives thereof; and a liquid crystalline structure-forming aid. The omega-3-fatty acid composition forms self-assembled lyotropic liquid crystals which are thermodynamically stable in structure, irrespective of digestion in the gastrointestinal tract, thereby promoting the solubilization and absorption rate of omega-3-fatty acids as well as providing preparations 30% or more smaller in size than conventional soft gel capsules of omega-3-fatty acid preparations. Thus, the composition can be taken with more ease by geriatric patients and the like and allows for provision of omega-3-fatty acid preparations increasing in in-vivo dissolution and absorption. La présente invention concerne une composition d'acides gras oméga 3 formant une structure cristalline liquide et, plus particulièrement, porte sur une composition d'acides gras oméga 3 comprenant : des lipides amphotères qui forment des structures cristallines liquides lorsqu'ils sont exposés à des milieux aqueux tels que le fluide gastro-intestinal ; des acides gras oméga 3 ou des dérivés de ceux-ci ; et un auxiliaire de formation de structure cristalline liquide. La composition d'acides gras oméga 3 forme des cristaux liquides lyotropes auto-assemblés qui sont de structure thermodynamiquement stable, indépendamment de la digestion dans le tractus gastro-intestinal, ce qui permet de favoriser la solubilisation et le taux d'absorption d'acides gras oméga 3 ainsi que de fournir des préparations d'une taille plus petite de 30 % ou plus que les capsules en gel mou classiques de préparations d'acides gras oméga 3. Ainsi, la composition peut être prise plus facilement par des patients gériatriques et analogues et permet d'augmenter la fourniture de préparations d'acides gras oméga 3 dans une dissolution et une absorption in vivo. 본 발명은 액상결정 구조체를 형성하는 오메가-3-지방산 조성물에 관한 것으로, 보다 상세하게는 위장관액과 같은 수성 매질에 노출 시, 액상결정 구조체를 형성하는 양쪽성 지질과 오메가-3 지방산 또는 이의 유도체 및 액상결정 구조 형성 보조제를 포함하는 오메가-3 지방산 조성물을 제공함으로써 위장관에서 소화와 무관하게 열역학적으로 안정한 구조의 농도전이형 액상결정을 자발적으로 형성함으로써 오메가-3-지방산의 가용화 및 흡수율을 촉진시킬 뿐 아니라, 이를 통하여 종래의 오메가-3-지방산 제제의 연질캡슐보다 30% 이상 축소된 제형을 제공하여 고령 환자군 등의 복용 용이성을 개선시키고, 체내 용출 및 흡수가 증가된 오메가-3-지방산 제제를 제공할 수