BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE
Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibi...
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| creator | RAGHU, Hari MUNDEL, Peter H DANIELS, Matthew H YU, Maolin HARMANGE, Jean-Christophe P DAGON, Yossi LEDEBOER, Mark W COEFFET-LE GAL, Marie-Francoise Yveline REILLY, John Francis |
| description | Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.
L'invention concerne des composés ayant des formules structurales (I)-(XI), et des compositions pharmaceutiques associées. L'invention concerne également des procédés de sélection et de traitement de sujets humains atteints d'une maladie rénale, à l'aide des composés de formules (I)-(XI), et des procédés de détermination de l'efficacité de thérapies à base d'inhibiteurs de TRPC5 l'utilisant. |
| format | Patent |
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L'invention concerne des composés ayant des formules structurales (I)-(XI), et des compositions pharmaceutiques associées. L'invention concerne également des procédés de sélection et de traitement de sujets humains atteints d'une maladie rénale, à l'aide des composés de formules (I)-(XI), et des procédés de détermination de l'efficacité de thérapies à base d'inhibiteurs de TRPC5 l'utilisant.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210408&DB=EPODOC&CC=WO&NR=2021067946A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210408&DB=EPODOC&CC=WO&NR=2021067946A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAGHU, Hari</creatorcontrib><creatorcontrib>MUNDEL, Peter H</creatorcontrib><creatorcontrib>DANIELS, Matthew H</creatorcontrib><creatorcontrib>YU, Maolin</creatorcontrib><creatorcontrib>HARMANGE, Jean-Christophe P</creatorcontrib><creatorcontrib>DAGON, Yossi</creatorcontrib><creatorcontrib>LEDEBOER, Mark W</creatorcontrib><creatorcontrib>COEFFET-LE GAL, Marie-Francoise Yveline</creatorcontrib><creatorcontrib>REILLY, John Francis</creatorcontrib><title>BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE</title><description>Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.
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L'invention concerne des composés ayant des formules structurales (I)-(XI), et des compositions pharmaceutiques associées. L'invention concerne également des procédés de sélection et de traitement de sujets humains atteints d'une maladie rénale, à l'aide des composés de formules (I)-(XI), et des procédés de détermination de l'efficacité de thérapies à base d'inhibiteurs de TRPC5 l'utilisant.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE |
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