BIOMARKER-BASED TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND DIABETIC KIDNEY DISEASE

Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibi...

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Bibliographische Detailangaben
Hauptverfasser:	RAGHU, Hari, MUNDEL, Peter H, DANIELS, Matthew H, YU, Maolin, HARMANGE, Jean-Christophe P, DAGON, Yossi, LEDEBOER, Mark W, COEFFET-LE GAL, Marie-Francoise Yveline, REILLY, John Francis
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same. L'invention concerne des composés ayant des formules structurales (I)-(XI), et des compositions pharmaceutiques associées. L'invention concerne également des procédés de sélection et de traitement de sujets humains atteints d'une maladie rénale, à l'aide des composés de formules (I)-(XI), et des procédés de détermination de l'efficacité de thérapies à base d'inhibiteurs de TRPC5 l'utilisant.