SENESCENT CELL-ASSOCIATED ANTIGEN-BINDING DOMAINS, ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS COMPRISING THE SAME, AND USES THEREOF

SENESCENT CELL-ASSOCIATED ANTIGEN-BINDING DOMAINS, ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS COMPRISING THE SAME, AND USES THEREOF

The invention relates to DEP1-binding domains and DPP4-binding domains, as well as antibodies and chimeric antigen receptors (CAR) comprising the same. Also disclosed are uses and methods for treating, preventing or alleviating senescence-related diseases or disorders, or for depleting and/or killin...

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Bibliographische Detailangaben
Hauptverfasser: MATHIEU, Thierry, OGRUNC, Müge
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to DEP1-binding domains and DPP4-binding domains, as well as antibodies and chimeric antigen receptors (CAR) comprising the same. Also disclosed are uses and methods for treating, preventing or alleviating senescence-related diseases or disorders, or for depleting and/or killing senescent cells. L'invention concerne des domaines de liaison à DEP1 et des domaines de liaison à DPP4, ainsi que des anticorps et des récepteurs antigéniques chimériques (CAR) les comprenant. L'invention concerne également des utilisations et des procédés pour traiter, prévenir ou soulager des maladies ou des troubles liés à la sénescence, ou pour dépléter et/ou tuer des cellules sénescentes.