METHODS OF SCREENING FOR CONDENSATE-ASSOCIATED SPECIFICITY AND USES THEREOF

Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifyi...

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Bibliographische Detailangaben
Hauptverfasser:	POSER, Ina, MURCKO, Mark Andrew, HALE, Stephen Paul, SZEWCZAK, Alexander, BEUTEL, Bruce Aaron
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided. L'invention concerne des procédés d'identification d'un composé, tel qu'un composé d'essai, et leurs applications. Par exemple, des procédés d'identification d'un composé qui affecte, augmente ou diminue préférentiellement un niveau d'association d'une macromolécule avec un ou plusieurs condensats cibles ou des procédés d'identification d'un composé qui provoque préférentiellement l'association ou la dissociation d'une macromolécule avec un ou plusieurs condensats cibles. De plus, l'invention concerne des procédés de conception et/ou d'identification et/ou de préparation d'un composé, ou d'une partie de ceux-ci, avec une caractéristique souhaitée.