PROCESSES FOR THE SYNTHESIS OF VALBENAZINE

The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatme...

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Bibliographische Detailangaben
Hauptverfasser:	KUCERA, David, HETTINGER, Donald, MCGEE, Kevin, COCHRAN, Brian M, LE, Jackie, TUCKER, John, BRANUM, Shawn
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD). La présente invention concerne des procédés de préparation de (S)-2-amino-3-méthylbutanoate et di(4-méthylbenzenesulfonate) de (2R,3R,11bR)-3-isobutyl-9,10-diméthoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoléin-2-yle, qui est un inhibiteur du transporteur vésiculaire des monoamines 2 (VMAT2), utile dans le traitement du trouble des mouvements hyperkinétiques, tel que la dyskinésie tardive (DT).