CRYSTALLINE FORM OF A MULTI-TYROSINE KINASE INHIBITOR, METHOD OF PREPARATION, AND USE THEREOF

CRYSTALLINE FORM OF A MULTI-TYROSINE KINASE INHIBITOR, METHOD OF PREPARATION, AND USE THEREOF

The present invention relates to crystalline forms of N-(3 -fluoro-4-((2-(5-(((2- methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4- fluorophenyl)cyclopropane- 1,1 -di carboxamide (Compound 1), pharmaceutical compositions comprising the crystalline form, processes for...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RAEPPEL, Stephane, RAEPPEL, Franck
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present invention relates to crystalline forms of N-(3 -fluoro-4-((2-(5-(((2- methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4- fluorophenyl)cyclopropane- 1,1 -di carboxamide (Compound 1), pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore. La présente invention concerne des formes cristallines de N-(3 -fluoro-4-((2-(5-(((2- méthoxyéthyl)amino)méthyl)pyridin-2-yl)thiéno[3,2-b]pyridin-7-yl)oxy)phényl)-N-(4-fluorophényl)cyclopropane-1,1-di carboxamide (composé 1), des compositions pharmaceutiques comprenant la forme cristalline, des procédés de préparation de la forme cristalline et des procédés d'utilisation de ceux-ci.