CYCLIC DINUCLEOTIDE STING AGONISTS TETHERED TO A PD-1 OR CTLA-4 ANTIBODIES

CYCLIC DINUCLEOTIDE STING AGONISTS TETHERED TO A PD-1 OR CTLA-4 ANTIBODIES

Disclosed are antibody-drug conjugates and compositions thereof for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof. L'invention concerne des conjugués anticorps-médicament et des compositions de ceux-ci pour l&#...

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Bibliographische Detailangaben
Hauptverfasser: PADMANABHAN, Seetharamaiyer, GIMI, Rayomand H, CLEARY, Dillon, SHERI, Anjaneyulu, SCHMIDT, Diane, IYER, Radhakrishnan P, BASKARAN, Subramanian
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Beschreibung
Zusammenfassung:Disclosed are antibody-drug conjugates and compositions thereof for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof. L'invention concerne des conjugués anticorps-médicament et des compositions de ceux-ci pour l'activation ou l'induction de l'expression d'un récepteur de reconnaissance de motifs (par exemple, STING, RIG-I, MDA5), et leurs procédés d'utilisation.