MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS

MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS

Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimers disease, and Alzheimers disease related disorder, and dise...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CARLSEN, Marianne, REITZ, Allen B, BINDER, Randall J, JIN, Xiao, SMITH, Garry R, REMEUR, Camille
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimers disease, and Alzheimers disease related disorder, and disease that involve excess amounts of TDP-43 in the cytosol. L'invention concerne des compositions pharmaceutiques comprenant des agents de liaison à TDP-43 ayant une action de modification de maladie dans le traitement de maladies associées à la TDP-43 qui comprennent la SLA, le FTLD, le CTE, la sclérose temporale mésiale du vieillissement (CARTS), la maladie d'alzheimer, et un trouble associé à la maladie d'alzheimer, et une maladie qui impliquent des quantités excessives de TDP-43 dans le cytosol.