IMMUNOGENIC COMPOSITION COMPRISING MULTIVALENT STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES

The present invention relates to an immunogenic composition comprising multivalent Streptococcus pneumoniae polysaccharide-protein conjugates. The respective conjugates comprise capsular polysaccharides of different Streptococcus pneumoniae serotypes conjugated to carrier proteins, and thus can indu...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Pan Kyeom, CHWA, Jun Won, JO, Kyung Min, CHA, Ji Hyoun, LEE, Soo Young, LA, Wan Geun
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an immunogenic composition comprising multivalent Streptococcus pneumoniae polysaccharide-protein conjugates. The respective conjugates comprise capsular polysaccharides of different Streptococcus pneumoniae serotypes conjugated to carrier proteins, and thus can induce immune responses to a wider variety of serotypes compared with existing Prevenar 13. The multivalent immunogenic composition according to the present invention can be advantageously used in preventing diseases caused by Streptococcus pneumoniae in infants, children, and adults. La présente invention concerne une composition immunogène comprenant des conjugués de protéine-polysaccharide de Streptococcus pneumoniae. Les conjugués respectifs comprennent des polysaccharides capsulaires de différents sérotypes de Streptococcus pneumoniae conjugués à des protéines porteuses, et peuvent ainsi induire des réponses immunitaires à une variété plus étendue de sérotypes par comparaison avec le Prevenar 13 existant. La composition immunogène multivalente selon la présente invention peut être avantageusement utilisée dans la prévention de maladies provoquées par Streptococcus pneumoniae chez les nourrissons, les enfants et les adultes. 본 발명은 다가 폐렴구균 다당류-단백질 접합체를 포함하는 면역원성 조성물에 관한 것이다. 각 접합체는 운반체 단백질에 접합된 상이한 폐렴구균 혈청형의 협막 다당류를 포함함으로써, 기존 프리베나13 대비 더욱 다양한 혈청형에 대하여 면역 반응을 유도할 수 있다. 본 발명에 따른 다가 면역원성 조성물은 영·유아, 소아 및 성인의 폐렴구균에 의한 질환을 예방하는데 유용하게 사용될 수 있다.