PROCESS FOR OBTAINING A FREEZE-DRIED COMPOSITION OF CHITOSAN-BASED NANOPARTICLES CONTAINING BROMELAIN, FREEZE-DRIED COMPOSITION OF CHITOSAN-BASED NANOPARTICLES CONTAINING BROMELAIN AND USE IN THE TREATMENT OF WOUNDS

The present invention relates to a process for obtaining a freeze-dried composition of chitosan nanoparticles containing bromelain. Said composition was seen to be stable in relation to enzyme activity using small molecules, such as sugars or amino acids, as freeze-drying additives. In addition, the present invention discloses the use thereof in preparing a medication for treating wounds. La présente invention concerne un procédé d'obtention d'une composition lyophilisée de nanoparticules de chitosane contenant de la broméline. Ladite composition s'est révélée stable par rapport à l'activité enzymatique utilisant de petites molécules, notamment des sucres ou des acides aminés comme lyoprotecteurs. En outre, la présente invention concerne son utilisation dans la préparation d'un médicament pour le traitement de plaies. A presente invenção refere-se a um processo de obtenção de uma composição liofilizada de nanopartículas de quitosana contendo bromelina. Dita composição revelou-se estável em relação à atividade enzimática utilizando pequenas moléculas, como açúcares ou aminoácidos como lioprotetores. Adicionalmente, a presente invenção revela seu uso na preparação de um medicamento para tratar de feridas.