CXCR6 INHIBITORS AND METHODS OF USE

CXCR6 INHIBITORS AND METHODS OF USE

Provided herein are small molecule inhibitors of CXCR6 receptor, compositions comprising the compounds, and methods of using the compounds and compositions. The compounds are 9-azbicyclo[3.3.1]nonane or 9-diazbicyclo[3.3.1]nonane derivatives, whose synthesis is also described. Also provided are meth...

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Bibliographische Detailangaben
Hauptverfasser: PEDDIBHOTLA, Satyamaheshwar, SESSIONS, Hampton, KIRBY, Richard, PINKERTON, Anthony, HERSHBERGER, Paul, MALANY, Siobhan, MALONEY, Patrick, SMITH, Layton, DIVLIANSKA, Daniela
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are small molecule inhibitors of CXCR6 receptor, compositions comprising the compounds, and methods of using the compounds and compositions. The compounds are 9-azbicyclo[3.3.1]nonane or 9-diazbicyclo[3.3.1]nonane derivatives, whose synthesis is also described. Also provided are method of treating a disease or condition (such as, cancer) mediated by CXCR6/CXCL16 signaling pathway in a mammal. L'invention concerne des petites molécules inhibitrices du récepteur CXCR6, des compositions comprenant ces composés et des procédés d'utilisation de ces composés et de ces compositions.