MODIFIED NUCLEOSIDE, NUCLEOTIDE AND MODIFIED NUCLEIC ACID POLYMER, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present disclosure relates to the technical field of nucleic acid medicines, in particular to a modified nucleoside, a nucleotide and a modified nucleic acid polymer, as well as a preparation method therefor and an application thereof. The modified nucleoside is selected from a compound having the following structure or a salt thereof: formula (1). According to the modified nucleoside of the present disclosure, an azido group, an amino group or an amine group and the like are introduced at a 4' position by means of modifying the nucleoside, and a novel modified nucleoside structure is obtained. The modified nucleoside may be further modified to obtain the nucleotide and the modified nucleic acid polymer, and has good ribozyme tolerance. La présente invention relève du domaine technique des médicaments à base d'acides nucléiques, et concerne en particulier un nucléoside modifié, un nucléotide et un polymère d'acide nucléique modifié, ainsi qu'un procédé de préparation correspondant et une utilisation assoc