COMPOSITION FOR PREVENTING OR TREATING CANCER

The present invention pertains to a composition capable of preventing or treating cancers, and in particular, pancreatic cancer. The composition can effectively inhibit the growth or proliferation of cancer cells, and furthermore, effectively prevent the resistance thereof to anticancer agents, or t...

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Bibliographische Detailangaben
Hauptverfasser: JEON, Ji Won, KIM, So Young, YEO, A Reum, LEE, Hyung Keun, CHANG, Eun-Ju
Format: Patent
Sprache:eng ; fre ; kor
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Zusammenfassung:The present invention pertains to a composition capable of preventing or treating cancers, and in particular, pancreatic cancer. The composition can effectively inhibit the growth or proliferation of cancer cells, and furthermore, effectively prevent the resistance thereof to anticancer agents, or the metastasis or recurrence of cancer, by using at least one activation inhibitor among interleukin-10 receptor subunit beta (IL-10RB, IL-10R2) and interleukin-22 (IL-22), or using an expression inhibitor of genes encoding at least one among the interleukin-10 receptor beta and interleukin-22. La présente invention concerne une composition capable de prévenir ou de traiter des cancers, et en particulier le cancer du pancréas. La composition peut de façon efficace inhiber la croissance ou la prolifération des cellules cancéreuses, et, de plus, peut de façon efficace prévenir leur résistance aux agents anticancéreux, ou prévenir la métastase ou la récurrence du cancer, à l'aide d'au moins un inhibiteur de l'activation choisi entre la sous-unité bêta du récepteur de l'interleukine-10 (IL-10 RB, IL-10 R2) et l'interleukine-22 (IL-22), ou à l'aide d'un inhibiteur de l'expression des gènes codant pour au moins une des protéines choisies entre le récepteur de l'interleukine-10 bêta et l'interleukine-22. 본 발명은 암 중에서도 특히 췌장암을 예방 또는 치료할 수 있는 조성물에 관한 것으로, 인터루킨-10 수용체 베타 서브유닛(interleukin-10 receptor subunit beta; IL-10RB, IL-10R2) 및 인터루킨-22(interleukin-22; IL-22) 중 적어도 하나의 활성 억제제; 또는 상기 인터루킨-10 수용체 베타 및 인터루킨-22 중 적어도 하나를 암호화는 유전자의 발현 억제제;를 사용하여 암 세포의 성장 또는 증식을 효과적으로 억제하고, 나아가서는 항암제에 대한 내성이나, 암의 전이 또는 재발 또한 효과적으로 방지할 수 있다.