PREPARATION METHOD FOR 4-FLUORINE-3-METHOXYL-5-METHYLANILINE HYDROCHLORIDE

The present invention relates to the field of organic synthesis. Provided is a preparation method for 4-fluorine-3-methoxyl-5-methylaniline hydrochloride. A synthetic route of the preparation method for 4-fluorine-3-methoxyl-5-methylaniline hydrochloride is route (I). The preparation method for 4-fl...

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Hauptverfasser: LUO, Jianye, ZHUANG, Mingchen, LI, Xianjun, GUO, Peng
Format: Patent
Sprache:chi ; eng ; fre
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Zusammenfassung:The present invention relates to the field of organic synthesis. Provided is a preparation method for 4-fluorine-3-methoxyl-5-methylaniline hydrochloride. A synthetic route of the preparation method for 4-fluorine-3-methoxyl-5-methylaniline hydrochloride is route (I). The preparation method for 4-fluorine-3-methoxyl-5-methylaniline hydrochloride takes cheap and readily available 5-bromine-2-fluorotoluene as a starting material to prepare 4-fluorine-3-methoxyl-5-methylaniline hydrochloride by a 5-step reaction. The method is convenient in technological operation, low in costs, safe, high in total yield, environment-friendly and suitable for industrial production and has a wide application prospect. La présente invention concerne le domaine de la synthèse organique. L'invention concerne un procédé de préparation de chlorhydrate de 4-fluor-3-méthoxyl-5-méthylaniline. Une voie synthétique du procédé de préparation du chlorhydrate de 4-fluor-3-méthoxyl-5-méthylaniline est la voie (I). Le procédé de préparation du