LIGAND DISCOVERY AND GENE DELIVERY VIA RETROVIRAL SURFACE DISPLAY

Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non- viral membrane-bound protein comprising a membrane-bound domain a...

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Bibliographische Detailangaben
Hauptverfasser:	BIRNBAUM, Michael, DOBSON, Connor
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non- viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain. L'invention concerne des compositions de rétrovirus et leurs procédés d'utilisation pour l'apport de gènes, les rétrovirus comprenant une protéine d'enveloppe virale comprenant au moins une mutation qui diminue sa fonction native, une protéine liée à une membrane non virale comprenant un domaine lié à une membrane et un domaine de ciblage extracellulaire.