CRYSTALLINE FORM OF A BET-INHIBITOR AND MANUFACTURE THEREOF

The present invention relates to crystalline form 1 of 6-(3, 5-dimethylisoxazol-4-yl)-7- methoxy-3 -methyl- 1 -(pyridin-2-ylmethyl)quinolin-2( 1 H)-one (I) and to a method of manufacture thereof Compound (I) is a BET inhibitor useful in the treatment of cancer. La présente invention concerne la form...

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Bibliographische Detailangaben
Hauptverfasser:	LUUKKONEN, Eila, STAFFANS, Anna, TOIS, Jan, MARLA, Roshaiah, ABBINENI, Chandrasekhar
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to crystalline form 1 of 6-(3, 5-dimethylisoxazol-4-yl)-7- methoxy-3 -methyl- 1 -(pyridin-2-ylmethyl)quinolin-2( 1 H)-one (I) and to a method of manufacture thereof Compound (I) is a BET inhibitor useful in the treatment of cancer. La présente invention concerne la forme cristalline 1 de 6-(3, 5-diméthylisoxazol-4-yl)-7-méthoxy-3-méthyl-1-(pyridin-2-ylméthyl))quinolin-2(1H)-one (I) et un procédé de fabrication de celui-ci. Le composé (I) est un inhibiteur BET utile dans le traitement du cancer.