COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF

COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF

The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT. La présente inven...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, Matthew R, COE, Samuel, DOMINGUEZ, Celia, BARD, Jonathan, LIU, Longbin, PRIME, Michael Edward
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT. La présente invention concerne de manière générale des composés qui se lient simultanément à la fois à la protéine huntingtine mutante (mHTT) et à une ubiquitine E3 ligase et leur utilisation en tant qu'agents thérapeutiques, par exemple, dans le traitement de maladies, telles que des troubles neurodégénératifs provoqués par l'agrégation de mHTT.