NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF

The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds. La présente invention c...

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Bibliographische Detailangaben
Hauptverfasser:	GUO, Zufeng, AHMADI, Ali, LIU, Jun O, PENG, Hanjing, SUN, Zhaoli, QI, Le, WANG, Yuefan, PEIFFER, Brandon J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds. La présente invention concerne une nouvelle classe d'analogues de FK506 non-immunosupresseurs qui sont des agonistes de BMP sélectifs de la FKBP, à petites molécules ayant une puissance modeste pour la réparation et la régénération de tissus. L'invention concerne également des procédés de fabrication et d'utilisation de ces composés.