DIRECT CELL CONVERSION-BASED METHOD FOR DIFFERENTIATION OF NEURAL STEM CELLS INTO ASTROCYTES

The present invention relates to a method for efficiently differentiating neural stem cells into astrocytes and, more particularly, to a cell conversion-based method for more efficiently differentiating human neural stem cells into astrocytes that exhibit immune response suppression ability within a...

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Bibliographische Detailangaben
Hauptverfasser:	HONG, Sung Hoi, JANG, Ahyoung, CHOI, Kyung-Ah
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method for efficiently differentiating neural stem cells into astrocytes and, more particularly, to a cell conversion-based method for more efficiently differentiating human neural stem cells into astrocytes that exhibit immune response suppression ability within a short period of time. Unlike a conventional method, the method for differentiating neural stem cells into astrocytes by using a differentiation medium containing a combination of several cytokines, according to the present invention, involves a shortened differentiation time and has excellent differentiation efficiency, and the differentiated astrocytes exhibit immune response suppression ability, and thus can be useful as an agent for treating various brain diseases such as degenerative neurological diseases. La présente invention concerne un procédé pour différencier efficacement des cellules souches neurales en astrocytes et, plus particulièrement, un procédé basé sur la conversion de cellules pour différencier plus efficacement des cellules souches neurales humaines en astrocytes qui présentent une capacité de suppression de la réponse immunitaire en un court laps de temps. Contrairement à un procédé classique, le procédé de différenciation de cellules souches neurales en astrocytes à l'aide d'un milieu de différenciation contenant une combinaison de plusieurs cytokines, selon la présente invention, implique un temps de différenciation raccourci et a une excellente efficacité de différenciation, et les astrocytes différenciés présentent une capacité de suppression de la réponse immunitaire, et peuvent donc être utiles en tant qu'agent pour traiter diverses maladies cérébrales telles que des maladies neurologiques dégénératives. 본 발명은 신경줄기세포를 성상교세포로 효율적으로 분화시키는 방법에 관한 것으로, 더욱 자세하게는 세포전환 방법을 기반으로 빠른 시간 내에 보다 효율적으로 인간 신경줄기세포를 면역반응 억제능을 나타내는 성상교세포로 분화시키는 방법에 관한 것이다. 본 발명에 따른 여러 사이토카인의 조합을 포함하는 분화배지를 이용하여 신경줄기세포를 성상교세포로 분화시키는 방법은 기존의 방법과 달리 분화 시간이 단축되고 분화 효율이 우수하며, 분화된 성상교세포가 면역반응 억제능을 나타내므로 퇴행성 신경계 질환과 같은 다양한 뇌질환 치료제로 유용하다.