ANTISENSE OLIGONUCLEOTIDES TARGETING CARD9

The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SAI, Kristina Mary, FINE, Jay, WAHLE, Joe Adam, KLEIN, Elliott Sanford, SHEN, Fei, MOELHART HOEG, Anja, HAGEDORN, Peter, MBOW, Mouhamadou a/k/a Lamine
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to CARD9 pre-mRNA intron and exon sequences, which are capable of inhibiting the expression of CARD9 protein. Inhibition of CARD9 expression is beneficial for a range of medical disorders including inflammatory bowel disease, pancreatitis, IgA nephropathy, primary sclerosing cholangitis, cardiovascular disease, cancer and diabetes. La présente invention concerne des oligonucléotides LNA antisens (oligomères) complémentaires à des séquences d'introns et d'exon pré-ARNm de CARD9, qui sont aptes à inhiber l'expression de la protéine CARD9. L'inhibition de l'expression de CARD9 est bénéfique pour une gamme de troubles médicaux comprenant la maladie intestinale inflammatoire, la pancréatite, la néphropathie à IgA, l'angiocholite sclérosante primitive, la maladie cardiovasculaire, le cancer et le diabète.