RAPAMYCIN DERIVATIVES

The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of...

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Bibliographische Detailangaben
Hauptverfasser:	GLASS, David J, CONNOLLY, Michael, ROGGO, Silvio, PATTERSON, Andrew W, BONAZZI, Simone, SHAVLAKADZE, Tea, ZUEGER, Patrik, MIHALIC, Manuel
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein. L'invention concerne des dérivés de 32-déoxo-rapamycine de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, des compositions pharmaceutiques et des combinaisons pharmaceutiques comprenant un composé de formule (I), et leurs procédés de production. L'invention concerne également des procédés d'utilisation d'un composé de formule (I) ou d'un sel pharmaceutiquement acceptable de celui-ci pour traiter les maladies et les troubles décrits dans l'invention.