ANTI-BTLA ANTIBODIES

ANTI-BTLA ANTIBODIES

This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammator...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CORNALL, Richard John, PALUCH, Christopher Douglas, DAVIS, Simon John
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:This invention relates generally to antibodies or antigen binding fragments that bind to human B and T lymphocyte attenuator (BTLA) and uses thereof. More specifically, the invention relates to agonistic antibodies that bind human BTLA and modulate its activity, and their use in treating inflammatory, autoimmune and proliferative diseases and disorders. La présente invention concerne de manière générale des anticorps ou des fragments de liaison à l'antigène qui se lient à l'atténuateur des lymphocytes B et T humains (BTLA) et leurs utilisations. Plus spécifiquement, l'invention concerne des anticorps agonistes qui se lient à BTLA humain et modulent son activité, et leur utilisation dans le traitement de maladies et de troubles inflammatoires, auto-immuns et prolifératifs.