TERNARY MICELLAR COMPLEX COMPOSED OF A SIALOGLYCOSPHINGOLIPID, A THERAPEUTICALLY ACTIVE SUBSTANCE AND AN ANTIBODY
The invention relates to a pharmaceutical composition soluble in an aqueous solution, which is characterised in that it comprises sialoglycosphingolipids; polypeptides selected from the group comprising antibodies, fragments and variants of same; and at least one therapeutically active substance, fo...
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Zusammenfassung: | The invention relates to a pharmaceutical composition soluble in an aqueous solution, which is characterised in that it comprises sialoglycosphingolipids; polypeptides selected from the group comprising antibodies, fragments and variants of same; and at least one therapeutically active substance, forming a ternary micellar complex of sialoglycosphingolipid-therapeutically active substance-polypeptide in which the polypeptides are non-covalently associated with the micelles formed by the sialoglycosphingolipid and the therapeutically active substance.
Una composición farmaceútica soluble en solución acuosa caracterizada porque comprende sialoglicoesfingolípidos; polipéptidos seleccionados del conjunto comprendido por anticuerpos, fragmentos y variantes de los mismos; al menos una sustancia terapéuticamente activa; conformando un complejo micelar ternario, sialoglicoesfingolípido-Sustancia terapéuticamente activa-Polipéptido, donde dichos polipéptidos están asociados en forma no covalente con las micelas conformadas por dicho sialoglicoesfingolípidos y dicha sustancia terapéuticamente activa.
La présente invention concerne une composition pharmaceutique soluble en solution aqueuse caractérisée en ce qu'elle comprend des sialoglyco-sphingolipides; des polypeptides sélectionnés dans l'ensemble formé par des anticorps, des fragments et variants de ces derniers; au moins une substance thérapeutiquement active; formant un complexe micellaire ternaire, au sialoglyco-sphingolipide-substance thérapeutiquemnt active-polypeptide, lesquels polypeptides étant associés de manière non covalente aux micelles formées par lesdits sialoglyco-sphingolipides et ladite substance thérapeutiquemnt active. |
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