COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS

The present invention provides a class of compounds, which includes enantiomers and pharmaceutically acceptable salts thereof, that selectively and effectively inhibit Hakai-mediated ubiquitination, preferably without affecting Hakai protein levels, thereby representing excellent anti-cancer drugs u...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: CORTÉS CABRERA, Álvaro, FIGUEROA CONDE-VALVÍS, Angélica, MARTÍNEZ IGLESIAS, Olaia Antía, CARBALLO CASTOSA, Raquel, CASAS PAIS, Alba, GAGO BADENAS, Federico
Format: Patent
Sprache:eng ; fre
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator CORTÉS CABRERA, Álvaro
FIGUEROA CONDE-VALVÍS, Angélica
MARTÍNEZ IGLESIAS, Olaia Antía
CARBALLO CASTOSA, Raquel
CASAS PAIS, Alba
GAGO BADENAS, Federico
description The present invention provides a class of compounds, which includes enantiomers and pharmaceutically acceptable salts thereof, that selectively and effectively inhibit Hakai-mediated ubiquitination, preferably without affecting Hakai protein levels, thereby representing excellent anti-cancer drugs useful in the treatment of a variety of cancers, such as carcinomas, in particular, tumors arising from the epithelial layers of the gastrointestinal track including month (oral cancer), esophagus, stomach, and small and large intestines (such as rectal or colon cancer). It also includes skin cancer, mammary gland (breast cancer), pancreas cancer, lung cancer, head and neck cancer, liver cancer, ovary cancer, cervix cancer, uterus cancer, gallbladder cancer, penile cancer, and urinary bladder cancer (such as renal, prostate or bladder cancer). La présente invention concerne une classe de composés, qui comprend des énantiomères et des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent sélectivement et efficacement l'ubiquitination médiée par Hakai, de préférence sans affecter les niveaux de protéine Hakai, ce qui représente d'excellents médicaments anticancéreux utiles dans le traitement d'une variété de cancers, tels que des carcinomes, en particulier des tumeurs issues des couches épithéliales du tractus gastro-intestinal comprenant la bouche (cancer oral), l'œsophage, l'estomac et l'intestin grêle et le gros intestin (comme le cancer du rectum ou du côlon). Cela comprend également le cancer de la peau, de la glande mammaire (cancer du sein), le cancer du pancréas, le cancer du poumon, le cancer de la tête et du cou, le cancer du foie, le cancer de l'ovaire, le cancer du col de l'utérus, le cancer de l'utérus , le cancer de la vésicule biliaire, le cancer du pénis, et le cancer de la vessie urinaire (tel que le cancer du rein, de la prostate ou de la vessie).
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2020099652A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2020099652A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2020099652A13</originalsourceid><addsrcrecordid>eNqNi7EKwjAQQLs4iPoPB64WakWh4zW5msM21eaiOJUi6SRaqP-PDuLs9Hjw3jTqVV0da2-1AzEo4KgkJXym8gpoNVBR_Jyt4ZwFDB6Q44o0o5AGn_PJs7BF4dquAN3nFI4VWkUN6Mbv3Tya9N19DIsvZ9GyIFEmDsOzDePQ3cIjvNpLnSZpkmTZbpvievNf9QacoTYM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS</title><source>esp@cenet</source><creator>CORTÉS CABRERA, Álvaro ; FIGUEROA CONDE-VALVÍS, Angélica ; MARTÍNEZ IGLESIAS, Olaia Antía ; CARBALLO CASTOSA, Raquel ; CASAS PAIS, Alba ; GAGO BADENAS, Federico</creator><creatorcontrib>CORTÉS CABRERA, Álvaro ; FIGUEROA CONDE-VALVÍS, Angélica ; MARTÍNEZ IGLESIAS, Olaia Antía ; CARBALLO CASTOSA, Raquel ; CASAS PAIS, Alba ; GAGO BADENAS, Federico</creatorcontrib><description>The present invention provides a class of compounds, which includes enantiomers and pharmaceutically acceptable salts thereof, that selectively and effectively inhibit Hakai-mediated ubiquitination, preferably without affecting Hakai protein levels, thereby representing excellent anti-cancer drugs useful in the treatment of a variety of cancers, such as carcinomas, in particular, tumors arising from the epithelial layers of the gastrointestinal track including month (oral cancer), esophagus, stomach, and small and large intestines (such as rectal or colon cancer). It also includes skin cancer, mammary gland (breast cancer), pancreas cancer, lung cancer, head and neck cancer, liver cancer, ovary cancer, cervix cancer, uterus cancer, gallbladder cancer, penile cancer, and urinary bladder cancer (such as renal, prostate or bladder cancer). La présente invention concerne une classe de composés, qui comprend des énantiomères et des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent sélectivement et efficacement l'ubiquitination médiée par Hakai, de préférence sans affecter les niveaux de protéine Hakai, ce qui représente d'excellents médicaments anticancéreux utiles dans le traitement d'une variété de cancers, tels que des carcinomes, en particulier des tumeurs issues des couches épithéliales du tractus gastro-intestinal comprenant la bouche (cancer oral), l'œsophage, l'estomac et l'intestin grêle et le gros intestin (comme le cancer du rectum ou du côlon). Cela comprend également le cancer de la peau, de la glande mammaire (cancer du sein), le cancer du pancréas, le cancer du poumon, le cancer de la tête et du cou, le cancer du foie, le cancer de l'ovaire, le cancer du col de l'utérus, le cancer de l'utérus , le cancer de la vésicule biliaire, le cancer du pénis, et le cancer de la vessie urinaire (tel que le cancer du rein, de la prostate ou de la vessie).</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200522&amp;DB=EPODOC&amp;CC=WO&amp;NR=2020099652A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20200522&amp;DB=EPODOC&amp;CC=WO&amp;NR=2020099652A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CORTÉS CABRERA, Álvaro</creatorcontrib><creatorcontrib>FIGUEROA CONDE-VALVÍS, Angélica</creatorcontrib><creatorcontrib>MARTÍNEZ IGLESIAS, Olaia Antía</creatorcontrib><creatorcontrib>CARBALLO CASTOSA, Raquel</creatorcontrib><creatorcontrib>CASAS PAIS, Alba</creatorcontrib><creatorcontrib>GAGO BADENAS, Federico</creatorcontrib><title>COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS</title><description>The present invention provides a class of compounds, which includes enantiomers and pharmaceutically acceptable salts thereof, that selectively and effectively inhibit Hakai-mediated ubiquitination, preferably without affecting Hakai protein levels, thereby representing excellent anti-cancer drugs useful in the treatment of a variety of cancers, such as carcinomas, in particular, tumors arising from the epithelial layers of the gastrointestinal track including month (oral cancer), esophagus, stomach, and small and large intestines (such as rectal or colon cancer). It also includes skin cancer, mammary gland (breast cancer), pancreas cancer, lung cancer, head and neck cancer, liver cancer, ovary cancer, cervix cancer, uterus cancer, gallbladder cancer, penile cancer, and urinary bladder cancer (such as renal, prostate or bladder cancer). La présente invention concerne une classe de composés, qui comprend des énantiomères et des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent sélectivement et efficacement l'ubiquitination médiée par Hakai, de préférence sans affecter les niveaux de protéine Hakai, ce qui représente d'excellents médicaments anticancéreux utiles dans le traitement d'une variété de cancers, tels que des carcinomes, en particulier des tumeurs issues des couches épithéliales du tractus gastro-intestinal comprenant la bouche (cancer oral), l'œsophage, l'estomac et l'intestin grêle et le gros intestin (comme le cancer du rectum ou du côlon). Cela comprend également le cancer de la peau, de la glande mammaire (cancer du sein), le cancer du pancréas, le cancer du poumon, le cancer de la tête et du cou, le cancer du foie, le cancer de l'ovaire, le cancer du col de l'utérus, le cancer de l'utérus , le cancer de la vésicule biliaire, le cancer du pénis, et le cancer de la vessie urinaire (tel que le cancer du rein, de la prostate ou de la vessie).</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwjAQQLs4iPoPB64WakWh4zW5msM21eaiOJUi6SRaqP-PDuLs9Hjw3jTqVV0da2-1AzEo4KgkJXym8gpoNVBR_Jyt4ZwFDB6Q44o0o5AGn_PJs7BF4dquAN3nFI4VWkUN6Mbv3Tya9N19DIsvZ9GyIFEmDsOzDePQ3cIjvNpLnSZpkmTZbpvievNf9QacoTYM</recordid><startdate>20200522</startdate><enddate>20200522</enddate><creator>CORTÉS CABRERA, Álvaro</creator><creator>FIGUEROA CONDE-VALVÍS, Angélica</creator><creator>MARTÍNEZ IGLESIAS, Olaia Antía</creator><creator>CARBALLO CASTOSA, Raquel</creator><creator>CASAS PAIS, Alba</creator><creator>GAGO BADENAS, Federico</creator><scope>EVB</scope></search><sort><creationdate>20200522</creationdate><title>COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS</title><author>CORTÉS CABRERA, Álvaro ; FIGUEROA CONDE-VALVÍS, Angélica ; MARTÍNEZ IGLESIAS, Olaia Antía ; CARBALLO CASTOSA, Raquel ; CASAS PAIS, Alba ; GAGO BADENAS, Federico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2020099652A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2020</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CORTÉS CABRERA, Álvaro</creatorcontrib><creatorcontrib>FIGUEROA CONDE-VALVÍS, Angélica</creatorcontrib><creatorcontrib>MARTÍNEZ IGLESIAS, Olaia Antía</creatorcontrib><creatorcontrib>CARBALLO CASTOSA, Raquel</creatorcontrib><creatorcontrib>CASAS PAIS, Alba</creatorcontrib><creatorcontrib>GAGO BADENAS, Federico</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CORTÉS CABRERA, Álvaro</au><au>FIGUEROA CONDE-VALVÍS, Angélica</au><au>MARTÍNEZ IGLESIAS, Olaia Antía</au><au>CARBALLO CASTOSA, Raquel</au><au>CASAS PAIS, Alba</au><au>GAGO BADENAS, Federico</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS</title><date>2020-05-22</date><risdate>2020</risdate><abstract>The present invention provides a class of compounds, which includes enantiomers and pharmaceutically acceptable salts thereof, that selectively and effectively inhibit Hakai-mediated ubiquitination, preferably without affecting Hakai protein levels, thereby representing excellent anti-cancer drugs useful in the treatment of a variety of cancers, such as carcinomas, in particular, tumors arising from the epithelial layers of the gastrointestinal track including month (oral cancer), esophagus, stomach, and small and large intestines (such as rectal or colon cancer). It also includes skin cancer, mammary gland (breast cancer), pancreas cancer, lung cancer, head and neck cancer, liver cancer, ovary cancer, cervix cancer, uterus cancer, gallbladder cancer, penile cancer, and urinary bladder cancer (such as renal, prostate or bladder cancer). La présente invention concerne une classe de composés, qui comprend des énantiomères et des sels pharmaceutiquement acceptables de ceux-ci, qui inhibent sélectivement et efficacement l'ubiquitination médiée par Hakai, de préférence sans affecter les niveaux de protéine Hakai, ce qui représente d'excellents médicaments anticancéreux utiles dans le traitement d'une variété de cancers, tels que des carcinomes, en particulier des tumeurs issues des couches épithéliales du tractus gastro-intestinal comprenant la bouche (cancer oral), l'œsophage, l'estomac et l'intestin grêle et le gros intestin (comme le cancer du rectum ou du côlon). Cela comprend également le cancer de la peau, de la glande mammaire (cancer du sein), le cancer du pancréas, le cancer du poumon, le cancer de la tête et du cou, le cancer du foie, le cancer de l'ovaire, le cancer du col de l'utérus, le cancer de l'utérus , le cancer de la vésicule biliaire, le cancer du pénis, et le cancer de la vessie urinaire (tel que le cancer du rein, de la prostate ou de la vessie).</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; fre
recordid cdi_epo_espacenet_WO2020099652A1
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title COMPOUNDS THAT SELECTIVELY AND EFFECTIVELY INHIBIT HAKAI-MEDIATED UBIQUITINATION, AS ANTI-CANCER DRUGS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T18%3A27%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CORT%C3%89S%20CABRERA,%20%C3%81lvaro&rft.date=2020-05-22&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2020099652A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true