ACTIVATABLE ANTI-CD166 ANTIBODIES AND METHODS OF USE THEREOF

ACTIVATABLE ANTI-CD166 ANTIBODIES AND METHODS OF USE THEREOF

Provided herein are activatable antibodies that when activated specifically bind to CD166 and conjugated activatable antibodies that specifically bind to CD166. Also provided are methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indicat...

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Bibliographische Detailangaben
Hauptverfasser: KAVANAUGH, W, HUMPHREY, Rachel, TERRETT, Jonathan, CARMAN, Lori, WILL, Matthias, WEAVER, Annie
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are activatable antibodies that when activated specifically bind to CD166 and conjugated activatable antibodies that specifically bind to CD166. Also provided are methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications. L'invention concerne des anticorps activables qui, une fois activés, se lient spécifiquement au CD166 et des anticorps activables conjugués qui se lient spécifiquement au CD166. L'invention concerne également des procédés de préparation et des méthodes d'utilisation de ces anticorps activables dans diverses indications thérapeutiques, diagnostiques et prophylactiques.