PHYTOCHEMICAL-FRUCTOOLIGOSACCHARIDE CONJUGATE, METHOD FOR PRODUCING SAME, AND USE THEREOF

The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide backbone. Compared to corresponding phenolic acid phytochemical...

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Bibliographische Detailangaben
Hauptverfasser:	MALIYAKKAL JOHNSON, Eldin, LEE, Han Ki, SUH, Joo Won
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DERIVATIVES THEREOF FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR RELEVANT APPARATUS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide backbone. Compared to corresponding phenolic acid phytochemicals, the novel phytochemical-fructooligosaccharide conjugate according to the present invention is hardly decomposed under oral-gastrointestinal transit conditions such that most of the phytochemical-fructooligosaccharide conjugate can reach the large intestine. Thus, the novel phytochemical-fructooligosaccharide conjugate has good bioavailability in the large intestine when orally administered. In particular, a ferulic acid-fructooligosaccharide conjugate according to the present invention has an excellent colorectal cancer cell-selective killing effect as compared to commercial colorectal cancer treatment drugs, and can thus be used as a food or pharmaceutical material useful for preventing, alleviating, or treating colorectal cancer. La présente invention concerne un nouveau conjugué agent phytochimique-fructo-oligosaccharide ayant une structure selon laquelle un agent phytochimique sous forme d'acide phénolique est conjugué à une partie de saccharides constituant un squelette de fructo-oligosaccharide. Par comparaison avec des produits phytochimiques d'acide phénolique correspondants, le nouveau conjugué agent phytochimique-fructo-oligosaccharide selon la présente invention est difficilement décomposé dans des conditions de transit gastro-intestinaux, de telle sorte que la majeure partie du conjugué agent phytochimique-fructo-oligosaccharide peut atteindre le gros intestin. Ainsi, le nouveau conjugué agent phytochimique-fructo-oligosaccharide présente une bonne biodisponibilité dans le gros intestin lorsqu'il est administré par voie orale. En particulier, un conjugué acide férulique-fructo-oligosaccharide selon la présente invention a un excellent effet d'élimination sélective de cellules du cancer colorectal par comparaison avec des médicaments de traitement du cancer colorectal présents dans le commerce, et peut ainsi être utilisé en tant que produit alimentaire ou pharmaceutique utile pour prévenir, soulager ou traiter le cancer colorectal. 본 발명은 페놀산(Phenolic acid) 형태의 파이토케미컬(Phytochemical)이 프럭토올리고당 주쇄를 구성하는 일부 당에 결합된 구조를 가지는 신규 파이토케미컬-프럭토올리고당 결합체를 제공한다. 본 발명에 따른 신규 파이토케미컬-프럭토올리고당 결합체는 이에 대응되는 페놀산 파이토케미컬에 비해 구강-위장관 통과 조건에서 거의 분해되지 않고 대부분이 대장에 도달할 수 있으므로 경구