PROCESSES FOR PREPARING A VMAT2 INHIBITOR

PROCESSES FOR PREPARING A VMAT2 INHIBITOR

The present invention relates to processes and intermediates for preparing (3R,11bS)-9,10-dimethoxy-2-methyl-3-neopentyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline, and salts thereof, which is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). The compounds and salts, solvate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KUCERA, David, CULHANE, Jeffrey C
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present invention relates to processes and intermediates for preparing (3R,11bS)-9,10-dimethoxy-2-methyl-3-neopentyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino[2,1-a]isoquinoline, and salts thereof, which is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). The compounds and salts, solvates, and hydrates thereof as described herein are useful in the treatment of neurological and psychiatric diseases and disorders. La présente invention concerne des procédés et des intermédiaires pour la préparation de (3R,11bS)-9,10-diméthoxy-2-méthyl-3-néopentyl-1,3,4,6,7,11b-hexahydro -2H-pyrazino[2,1-a]isoquinoline, et des sels de ceux-ci, qui est un inhibiteur du transporteur de monoamine vésiculaire 2 (VMAT2). Les composés et sels, solvates et hydrates de ceux-ci tels que décrits ici sont utiles dans le traitement de maladies et de troubles neurologiques et psychiatriques.