NONAPEPTIDE PREVENTING INCREASED HYPERPERMEABILITY OF VASCULAR ENDOTHELIUM

The invention relates to a low-toxicity, proteolysis-resistant biologically active nonapeptide of formula (I) that is capable of preventing vascular hyperpermeability in stressful situations. Owing to said property, the claimed peptide can be used in medicine as an anti-edematous agent. L'inven...

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Bibliographische Detailangaben
Hauptverfasser:	SAMSONOV, Mikhail Vasilievich, MOLOKOEDOV, Aleksandr Sergeevich, KAZAKOVA, Olga Alekseevna, KHAPCHAEV, Asker Yusufovich, AZMUKO, Andrey Andreevich, OVCHINNIKOV, Mihail Vladimirovich, SHIRINSKY, Vladimir Pavlovich, ARZAMASCEV, Yevgeniy Veniaminovich, BUSHUEV, Valeri Nikolaevich, TEREKHOVA, Olga Alexandrovna, PALKEEVA, Marina Yevgenievna, SIDOROVA, Mariya Vladimirovna
Format:	Patent
Sprache:	eng ; fre ; rus
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a low-toxicity, proteolysis-resistant biologically active nonapeptide of formula (I) that is capable of preventing vascular hyperpermeability in stressful situations. Owing to said property, the claimed peptide can be used in medicine as an anti-edematous agent. L'invention concerne un nonapeptide faiblement toxique et stable au plan protéolythique biologiquement actif ayant une formule (I) permettant de prévenir le développement d'une hyperperméabilité vasculaire en situations de stress. Grâce à cette propriété le peptide de l'invention peut s'utiliser en médecine humaine en tant que médicament contre les oedèmes. Изобретение относится к малотоксичному, протеолитически устойчивому биологически активному нонапептиду формулы (I), обладающему способностью предотвращать развитие сосудистой гиперпроницаемости в стрессовых ситуациях. Благодаря этому свойству заявляемый пептид может найти применение в медицине в качестве противоотечного средства.