T CELL MODIFICATION

The present invention relates to improved compositions and methods for treating diseases, such as cancer, by providing a cell immunotherapy, wherein the cell immunotherapy is an immunomodulatory cell expressing an exogenous CD8 co-receptor and a modified T cell receptor (TCR). The invention further...

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Bibliographische Detailangaben
Hauptverfasser:	SOUTHGATE, Thomas, ADAMS, Katherine, RICE, Louise, MELCHIORI, Luca, BRETT, Sara Jane, DAVIES, Marie L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to improved compositions and methods for treating diseases, such as cancer, by providing a cell immunotherapy, wherein the cell immunotherapy is an immunomodulatory cell expressing an exogenous CD8 co-receptor and a modified T cell receptor (TCR). The invention further relates to polynucleotides, expression vectors, and immunomodulatory cells comprising the immunotherapy, as well as methods of generating said immunomodulatory cells. La présente invention concerne des compositions et des procédés améliorés pour traiter des maladies, telles que le cancer, par la réalisation d'une immunothérapie cellulaire, l'immunothérapie cellulaire consistant en une cellule immunomodulatrice exprimant un co-récepteur CD8 exogène et un récepteur de lymphocytes T (TCR) modifié. L'invention concerne en outre des polynucléotides, des vecteurs d'expression et des cellules immunomodulatrices comprenant l'immunothérapie, ainsi que des procédés de génération desdites cellules immunomodulatrices.