SLOW RELEASE PASIREOTIDE MICROSPHERE AND PREPARATION METHOD THEREOF

Disclosed are a slow release pasireotide microsphere and a preparation method thereof. The microsphere is prepared using pasireotide as an active ingredient, and a microsphere support polymer, a protecting agent, a surfactant and a suspending agent. The microsphere support polymer is selected from polylactic-co-glycolic acids (PLGA). The suspending agent is selected from one or a combination of any two or more of tragacanth, gum arabic, carbomer and sodium alginate. The preparation method of the microsphere is a multiple emulsion method. Addition of the suspending agent allows for a release time of the pasireotide microsphere of up to 28 days. L'invention concerne une microsphère de pasiréotide à libération lente et son procédé de préparation. La microsphère est préparée à l'aide de pasiréotide en tant que principe actif, et d'un polymère support de microsphère, d'un agent de protection, d'un tensioactif et d'un agent de suspension. Le polymère support de microsphère est choisi parmi les acides polylactique-c