N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME

N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME

The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or weakening bacteria. In another aspect, the invention relates to me...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VAZQUEZ-TORRES, Andres, WEMPE, Michael Fitzpatrick, DAI, Shaodong
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to the discovery of novel N-(substituted)-1H-1,2,4-triazole-3-carboxamide compounds capable of inhibiting DksA activity in a bacteria cell. In certain embodiments, the compounds are capable of killing or weakening bacteria. In another aspect, the invention relates to methods of treating bacterial infection in a subject in need thereof, the method comprising administering to the subject a compound of the invention. La présente invention concerne la découverte de nouveaux composés 1H-1,2,4-triazole-3-carboxamide N-substitués permettant d'inhiber l'activité de DksA dans une cellule bactérienne. Dans certains modes de réalisation, les composés permettent de tuer ou d'affaiblir des bactéries. Selon un autre aspect, l'invention concerne des méthodes de traitement d'une infection bactérienne chez un sujet qui en a besoin, la méthode comprenant l'administration au sujet d'un composé selon l'invention.